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This variation in pharmacokinetics across GLP-1 is critical when considering each drugs suitability for pregnancy, as it directly impacts blood glucose control, convenience, and potential adherence in GDM management

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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]

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