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If constipation persists despite these measures, speak to your prescriber about possibly pausing dose escalation or temporarily reducing your dose until symptoms improve

Gynecol Endocrinol (2023) 39(1):2181652

2 In healthy individuals, a finely choreographed interaction between insulin and several counterregulatory hormones, including glucagon, epinephrine, cortisol, and growth hormone, ensures that blood glucose concentrations are maintained within the physiological range

The relationship is bidirectional and more complex than most people realize

doi: 10.1038/sj.bjp.0705453

The satiety cascade, first proposed in the 1980s and modified throughout, indicates that satiation and satiety are governed by the interplay of metabolic, cognitive, and sensory factors, which are interconnected components [31,33,34]