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Our review provides insights into the interplay of lifestyle factors, genetic predispositions, and the significant psychological and physiological burdens associated with managing these comorbid conditions

This is expected to change over time, which should increase competition and drive prices down but that's likely at least a year away, Barner said

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Patients who are entirely new to GLP-1 therapy and have no specific indication for the dual-agonist approach can reasonably start with semaglutide, given its longer real-world track record

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