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A systematic search of PubMed, Scopus, and Web of Science was conducted up to December 2024 according to PRISMA guidelines

Switching to the oral small molecule glucagon-like peptide-1 (GLP-1) orforglipron after taking injectable GLP-1s helped patients maintain mostbut not allof their weight loss, according to a clinical trial led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

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