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Phase 2 Trial Design Participants: 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27), without diabetes Duration: 48 weeks Dosing groups: Placebo, 1mg, 4mg, 8mg, or 12mg weekly (with gradual dose escalation over 20-24 weeks) Primary endpoint: Percentage change in body weight from baseline Beyond Weight Loss: Metabolic Improvements Beyond weight loss, the 12mg dose also improved several cardiometabolic markers: Blood pressure: Systolic BP decreased by 7.4 mmHg (clinically significant reduction) Lipids: Triglycerides fell 30%, HDL cholesterol increased 8% Glucose control: HbA1c decreased 0.4% even in participants without diabetes Liver health: Markers of fatty liver disease (ALT, AST) improved significantly Inflammation: C-reactive protein (CRP) decreased, indicating reduced systemic inflammation What this means: Retatrutide appears to improve the metabolic dysfunction behind obesity-related diseases, not just the weight itself

Our clinical mantra is cautious curiosity: we are curious enough to try new tools, but cautious enough to prioritize safety, transparency, and measurable goals

While we do prescribe weight loss medications to those who can safely benefit from them as part of their comprehensive weight loss strategy, it's important to note that not all patients will receive a prescription for medication

At TrimRx, we connect our patients with licensed healthcare providers who work with FDA-registered and inspected compounding pharmacies

Of these, two studies ( N = 16 and N = 46, respectively) observed a positive association between the use of exenatide, liraglutide or dulaglutide and weight loss as well as HbA1c at 16 weeks 149 and 1 year 150 , while for the smaller one ( N = 7) this association was not significant 148