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Guyatt, G

5.1 Limitations Most of the studies yet performed regarding SID and SIH employed observational designs, and data derived from randomised controlled clinical studies are lacking

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In the human body, the PLG polymers slowly degrade through the non-catalyzed hydrolysis of the ester linkages into lactic acid and glycolic acid, which are finally eliminated as carbon dioxide and water

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The resulting increase in intracellular cAMP activates protein kinase A (PKA) and exchange protein activated by cAMP 2 (Epac2)
