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Safety Considerations: Long-term use may be associated with vitamin B12 deficiency, hypomagnesemia, increased fracture risk, and infections such as Clostridioides difficile

[DOI] [PubMed] [Google Scholar] Montrose-Rafizadeh C, Egan JM, Roth J

For diabetic retinopathy, GLP-1RAs are associated with the early worsening phenomenon linked to rapid glycemic control, a signal not typically observed with SGLT2 inhibitors, which generally show a neutral or modestly protective effect

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The "better" drug produced worse outcomes because of lower persistence

Aim for vegetables that roast well at 425F and cut them to similar sizes so cooking times remain consistent