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10.1038/s41574-021-00473-6 [DOI] [PubMed] [Google Scholar] 74.Shaghouli AA, Ballani R, Mesbah N

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When to Seek Advice Contact your GP or diabetes specialist nurse if you experience: Persistent nausea or vomiting that prevents adequate fluid intake (risk of dehydration) Severe, persistent abdominal pain stop taking the medication and seek urgent medical attention as this could indicate pancreatitis Symptoms of hypoglycaemia if taking alongside insulin or sulfonylureas Severe abdominal pain radiating to the back, with or without fever or jaundice (yellowing of skin/eyes) may indicate gallbladder problems Unexplained weight loss or gain outside expected parameters If you're planning pregnancy, discuss with your healthcare provider

The pattern that emerges from the STEP clinical trials is remarkably consistent across thousands of participants

Obesity is a chronic medical condition driven by biology, not willpower

You have a spot where you sit during the hold period