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The most common GLP-1 side effects include: Nausea Diarrhea Vomiting Constipation Stomach pain A study from researchers at Mayo Clinic, presented in 2023, found that half of adults taking semaglutide, the active ingredient in Ozempic and Wegovy, experienced side effects, the most reported ones being nausea (38 percent) and diarrhea (9 percent)