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This effect is dose-dependent and typically decreases as your body acclimates

While this is part of how they help with appetite and weight, it can also lead to: Acid reflux A feeling of fullness or pressure Disrupted sleep (especially if reflux worsens at night) Even if youve been taking Akkermansia, it may not fully offset this effect because the root issue here is mechanical (slower stomach emptying) rather than purely microbial

Clin Gastroenterol Hepatol 2022

This has important implications for patient counseling, treatment planning, and cost-effectiveness analyses

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