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Description
Semaglutide is a GLP-1 receptor agonist injection that works by mimicking a natural hormone to reduce appetite and slow gastric emptying, whilst orlistat is an oral medication that blocks fat absorption in the intestine

In animal studies, GLP-1 changed how serotonin works in parts of the brain that regulate mood

Deacon C

doi: 10.1161/CIRCRESAHA.109.201590 120 GrabowskaWSikoraEBielak-ZmijewskaA

Semaglutide does not flip a switch

1) [97], suggesting redundant circuits mediating the suppression of food intake by 5-HT
