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doi: 10.1016/j.molmet.2020.101102 46

A New Paradigm for Treating to Target with Second-Generation Obesity Medications

Researchers collected data on weight change for up to 72 weeks
The exact mechanisms through which activation of THR improves MASH are still unclear but are known to control fat synthesis, regulate fatty acid oxidation, regulate cholesterol metabolism, improve mitochondrial function, and reduce inflammation and fibrosis

Not only that, the GLP-1 drugs also quiet inflammation, stimulate the production of antioxidants, help repair damaged DNA, and slow the aging of the body's cells

Currently, GLP-1s are probably most well-known for their weight loss effects, with studies showing people with overweight and obesity lose an average of 10 pounds or more using them
