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Some patients may take semaglutide (Ozempic) off-label for weight loss

GLP-1 RA use in complicated diabetes: There is no clear evidence regarding the use of GLP-1 RA in acute myocardial infarction, although the use of these agents is encouraged in patients with asymptomatic and stable coronary artery disease (CAD)

Research has shown that glucagon receptor activation increases resting energy expenditure

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Importantly, GIP receptor sensitivity is impaired in prolonged hyperglycemic states due to receptor downregulation but can be restored upon achieving euglycemia through complementary GLP-1 action [38,39]