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Gradual Weight Loss and Muscle Maintenance For those using GLP-1 drugs primarily for weight loss, microdosing might offer a more gradual weight loss experience, which some individuals believe helps preserve muscle mass

However, metformin is oral, inexpensive, and has an extensive safety record, making it the preferred initial therapy

Conflicting resultsneed for more transparent and reproducible research

Methods Protocol and registration No ethical approval was required as the current study involved analyzing and synthesizing previously published data and information from secondary use of deidentified electronic databases (Code of Federal Regulations, 45 CFR 46.102)

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Nutrition coaching exists but is practically inaccessible, with only one nutritionist and very limited availability