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While GLP-1 drugs can alter the chemistry of hunger in powerful ways, they dont necessarily help with the emotional and psychological factors often found at the root of eating disorders

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Because SUMO expression is increased in mouse islets exposed to high glucose (Rajan et al., 2012), its interaction with GLP-1R may in part contribute to the reduced efficacy of incretin therapies in some T2DM patients with poorly controlled hyperglycemia (Fritsche et al., 2000

GLP-1s may also improve cognitive health and recall in some people, thanks to their impact on inflammation in the brain and other dementia risk factors

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By stimulating glucose-dependent insulin secretion and suppressing glucagon production, they are a cornerstone of the treatment of type 2 diabetes (DM2), particularly in patients with a higher risk of cardiovascular disease ( This narrative review describes the complex interplay between GLP-1 signalling and intestinal inflammation, highlighting both the potential benefits and limitations of GLP1 RAs in IBD management, with a particular focus on their promising role in selected obese IBD patients