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2 Materials and methods 2.1 General computational methods Protein Data Bank (PDB) coordinates of the GLP-1GLP-1R (5VAI) (www.rcsb.org)

Olsson LM, Boulund F, Nilsson S et al (2022) Dynamics of the normal gut microbiota: a longitudinal one-year population study in Sweden

Under specific pathological conditions, such as Mycobacterium tuberculosis (MTB) infection, excessive HO-1-mediated iron release may overwhelm the cells antioxidant defenses, leading instead to increased lipid peroxidation and ferroptosis (76) ( Figure 2 )

Zepbound should be discontinued if pregnancy occurs, and patients should be advised that oral contraceptive effectiveness may be reduced during dose escalation

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JAMA 332 , 952953 (2024)