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deepening and accentuation of wrinkles and folds (eg, nasolabial folds, accordion or radial cheek lines, marionette lines)

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It is important to distinguish between mild, self-limiting constipation and more serious complications such as severe faecal impaction or, rarely, bowel obstruction

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This means the drug does not hit peak levels and stay there permanently

Semaglutide mimics the glucagon-like peptide-1 (GLP-1) hormone, which regulates blood sugar, slows stomach emptying, and activates brain regions controlling appetite and satiety