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GLP-1 RAs induce an increase in heart rate (HR), which, theoretically, represents a safety concern, as this is considered to be associated with higher cardiovascular risk [13, 14]

[DOI] [PubMed] [Google Scholar] 216.White JR

(2021, NEJM) reported the dose-response pharmacology that established tirzepatide as a distinct compound from the single-receptor class

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While gender was tested as a covariate in all analyses, the small sample size and low percentage of enrolled females did not allow us to investigate possible gender differences in endocrine outcomes after cannabis administration