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You want to minimize how much nausea, fatigue, and GI effects interfere with your daily life

How you time your meals, structure your exercise, and manage your sleep all influence how effectively the medication works
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And particularly with weight loss, it seems likely that public health interventions could also be effective if thats something we as a society really want

Total weight loss trajectories vary dramaticallysome patients lose 15-20 pounds in 3 months, while others see 8-10 pounds in the same timeframe, both representing successful outcomes

Woodard GA, Downey J, Hernandez-Boussard T, Morton JM

Whether the B12 actually mitigates the fatigue in practice is debated
