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Serious adverse events reported in temporal association with GLP-1 RA exposure included anaphylaxis with bronchospasm (n=4 cases), acute eosinophilic pneumonia (n=1), perioperative aspiration pneumonitis or pneumonia (multiple perioperative cases across two cohort studies and one case series), acute respiratory distress syndrome (ARDS

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For drugs with a narrow therapeutic index, other factors need to be monitored closely, including plasma drug levels, patients clinical outcomes, and laboratory markers

Tirzepatide, a novel GLP-1/GIP dual receptor agonist, shows significant advantages in glycemic management and weight control