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Semaglutide only activates the GLP-1 pathway

For many women, particularly those with PCOS, this is enough to restart ovulation

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Expected Weight Loss: In the head-to-head SURMOUNT-5 trial published in The New England Journal of Medicine , tirzepatide was shown to be superior to semaglutide for reduction in body weight and waist circumference at 72 weeks among adults with obesity (without diabetes)

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Semaglutide is approved for adults with a BMI of 30 or higher or a BMI of 27 or higher with a weight-related health condition, such as diabetes or high blood pressure