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Comparative data shows slightly higher rates of serious adverse events with high-dose tirzepatide (1015 mg)

This structural tweak gives semaglutide a half-life of approximately 7 days, enabling once-weekly dosing

From there, your provider will also consider things like: Improvements in blood sugar Changes in blood pressure Cholesterol levels How stable your weight has been over several weeks Once those pieces start lining up, your provider may start talking about a maintenance dose so you can keep your progress steady

Patients often ask whether their insurance, such as Aetna, will cover it

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