glp-1 receptor agonist kidney outcomes semaglutide flow trial 2024 results LANDMARK ALERT 🚨 REPRIEVE Trial results: Pitavastatin provides over 35% reduction in MACE in patients with HIV! Association of glucagon-like peptide-1 receptor

PMID: 40506769

GLP-1 receptors are present in Sertoli and Leydig cells, which means that these drugs have the potential to directly affect testicular function in addition to improving hormonal balance

A 2022 warning letter from the Office of Prescription Drug Promotion (OPDP) highlighted an Instagram ad posted by the company that reportedly made, false or misleading claims and representations about the benefits and risks of Trulicity. It found that the company minimized the risks and overemphasized the benefits of the drug

They are structurally distinct molecules with their own specific biological activities

However, it is considered an important risk factor for weight gain (16, 17) ( Figure 1 )

More patients with established cardiovascular disease in the liraglutide group were using beta-blockers, statins, angiotensin-converting enzyme inhibitors, and platelet aggregation inhibitors than in the placebo group, which might have skewed the results in favor of liraglutide