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doi: 10.1001/jama.288.20.2579

Zepbound is a dual GIP and GLP-1 receptor agonist, which means it activates both incretin pathways to enhance blood sugar control and support effective, long-term weight loss

doi: 10.1111/dom.14255

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Whilst declining beta-cell function is thought to generally reduce the response to incretins, GLP-1 appeared to be the more important incretin hormone in T2D (Nauck et al, 2021)

8 GIPR deficiency in mice leads to impaired glucose tolerance with reduced cell function, 9 while GIP overexpression results in improved glucose tolerance, enhanced cell function, and resistance to highfat dietinduced obesity