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This article reviews the clinical evidence, mechanisms, safety profile, and how genetic and biomarker assessments may inform personalized decisions
If you have MASH, GLP-1 medications may help treat the condition
In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year
Compare the 3 best online GLP-1 weight loss programs in 2026
GLP-1 agonist therapy helps manage type 2 diabetes and supports weight loss
