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1 Of those, 135 letters were based on an FDA inspection (inspection-based warning letters), including 16 letters issued to clinical investigators or sponsors following inspections conducted as part of the FDAs Bioresearch Monitoring (BIMO) Program

Despite producing greater weight loss, retatrutide's GI side effect rates in Phase 2 were lower than those reported in Wegovy's pivotal trials

Journal of Radiation Research and Applied Sciences

Because tirzepatide and semaglutide are relatively newer therapeutics, long-term side effects are not known

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Based on cohort studies of patients with obesity (irrespective of diabetes status) who were newly started on tirzepatide or semaglutide, tirzepatide is associated with significantly more weight loss than semaglutide [102]