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Mild side effects such as nausea, diarrhea, or a slight drop in energy levels may occur initially as your body adjusts to the medication

Carvalho, Brendon Stubbs, Yen-Wen Chen, Tien-Yu Chen, Wei-Te Lei, Po-Huang Chen, Jiann-Jy Chen, Yow-Ling Shiue, Bing-Syuan Zeng, Kuan-Pin Su, Chih-Sung Liang Journal of Hematology & Oncology.2025;[Epub] CrossRef Tirzepatide and Cancer Risk in Individuals with and without Diabetes: A Systematic Review and Meta-Analysis Fig

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While this approach is not part of the FDA-approved prescribing information, it raises interesting timing considerations that are worth addressing

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If you have documented B12 deficiency or absorption issues, the combination could provide genuine benefit