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Variants in the FTO gene (rs9939609), GLP1R gene (rs6923761), GIPR gene (rs1800437), and MC4R gene (rs17782313) influence appetite regulation, energy expenditure, and metabolic response to GLP-1 therapy
The most recent understanding of this deficit suggests that it relates to deterioration of the GLP-1 effect, with impaired capacity to secrete insulin, increasing insulin resistance, and hyperglycemia, perhaps leading to a decrease in GLP-1 receptor expression and resulting in GLP-1 resistance (7)
Don't skip your semaglutide dose without talking to your provider first, as sudden changes can affect your weight management progress
Symptoms of Kidney Injury: Decrease in the amount of urine, swelling in the extremities
