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Food and Drug Administration (FDA) has cited the Clayton, North Carolina facility of Novo Nordisk for issues with their quality control

These views are not necessarily endorsed or verified by the National Academy of Medicine or the National Academies of Sciences, Engineering, and Medicine and should not be construed as reflecting any group consensus

Some patients anecdotally report better tolerance when taking their injection in the evening, though there is no evidence that timing affects the medication's efficacy

Furthermore, diabetic rats treated with DPP4 inhibitors showed lower HbA1c levels compared to diabetic control animals

PMID 19164583