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The PBAC considered semaglutide for obesity at its March 2022 meeting and decided not to recommend the requested listing

Introduction The biological effects of the Glucagon-like peptide-1 (GLP-1) are mediated by binding to its receptor, GLP-1R, a specific seven-transmembrane receptor guanine nucleotide-binding protein (G-protein) coupled receptor (GPCR) (1)

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(18) described a change toward a less inflammatory state in animals treated with GLP-1 receptor agonists

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