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Diabetes Obes Metab 26(Suppl 4):1627 Xiang J, Qin L, Zhong J, Xia N, Liang Y (2023) GLP-1RA liraglutide and semaglutide improves Obesity-Induced muscle atrophy via SIRT1 pathway

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In head-to-head trials, tirzepatide 15mg vs semaglutide 1mg in type 2 diabetes showed greater A1c drop (~2.0% vs 1.4%) and greater weight loss (~11 kg vs 5 kg) ( [138] )

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These effects are highly individualized and require more research