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Overall, the current data provide important preliminary risk estimates to be used in the assessment of the overall riskbenefit relationship for using incretin-based medications, before results from more long-term outcome trials become available for meta-analyses

But the program didnt begin in earnest until December 2024 when CMS announced that the first round of drugs had been selected for the pilot

The leap from that signal to a direct, measurable difference in MRI-quantified brain atrophy has not yet been demonstrated in a clean randomized trial, which is precisely the gap TAG-MS is designed to close

There is also evidence that GLP-1RA has positive effect on metabolic syndrome and abdominal obesity

Gen Z led at 28%, followed by baby boomers (23%), millennials (22%), and Gen X (22%)

Progressive overload, where weight or reps increase over time, stimulates muscle retention and growth