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For the main analysis, changes in weight, BMI, HbA1c, and all-cause healthcare resource utilization (HCRU) after 1 year were compared among adjusted semaglutide OW and comparator SGLT2i cohorts, following inverse probability of treatment weighting (IPTW)

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These findings help researchers plan preclinical and translational work on integrated gutbrain hormone signaling, receptor interactions, and downstream pathways tied to weight and glucose regulation

Chi 2 test was used to analyze categorical variables

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