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Preclinical studies have suggested that GLP-1 receptors are expressed in thyroid tissue, and animal models have indicated possible anti-inflammatory effects that could theoretically influence autoimmune processes

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This means an unrefrigerated dose could deliver less peptide to your GLP-1 receptors, reducing appetite suppression and metabolic benefits

Potentially altering the hedonic response to food

Adding significant GLP-1-driven muscle loss on top of natural age-related decline can accelerate a process that was already working against you

Rapid weight loss can reduce mechanical stress on bones and sometimes decrease nutrient intake, both of which can contribute to lower bone density