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SODIUM-GLUCOSE COTRANSPORTER TYPE 2 (SGLT2) INHIBITORS They are antihyperglycemic agents that act on SGLT-2 proteins, expressed in the proximal convoluted tubules

They also performed insulin tolerance tests (ITT) in addition to GTT and saw an increased phosphorylation of Akt and reduced expression of gluconeogenic genes, concluding that DPP4-KO improved insulin sensitivity

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This physiological effect extends satiety duration, helping individuals feel satisfied with smaller food portions and reducing hunger frequency between meals