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Class B1 GPCRs bind their peptide agonists via a two-domain model, whereby the C-terminus of the peptide interacts with the receptor extracellular N-terminal domain (ECD) promoting an affinity trap that enables the engagement of the N-terminus of the peptide with the receptor transmembrane domain (TMD), with interactions with the TMD required for receptor activation 9

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Yang F., et al

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Its important to grasp this conversion clearly, as accurate dosing plays a crucial role in effective treatment and helps minimize potential side effects