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EMA statement on ongoing review of GLP-1 receptor agonists (suicidal thoughts and self-harm signal)

Those remain deeply human adaptations that still require guidance, structure, and repetition

The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary

These medications may affect the way the brain responds to dopamine signals in these areas, decreasing the overactive reward response that drives impulsivity and cravings for substances, she told Healthline
Based on these studies, the FDA has approved Strattera as a treatment for adult ADHD

2022;71(Suppl 1):729
