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![Figure][1] Graphical Abstract: ### Competing Interest Statement The FR + FMG laboratory receives funding from AstraZeneca, Eli Lilly and LGM for unrelated research and FMG consults for Kallyope (New York)

Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline