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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of bottom-up vs top-down recognition of covariates

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It also resulted in a 13.2% decrease in body weight in an East Asian population with overweight or obesity, with or without T2DM

This has led to the development and investigation of several incretin-related therapies such as unimolecular GLP-1/glucagon receptor dual agonists, GLP-1/gastric inhibitory polypeptide (GIP) dual agonists and GLP-1/GIP/glucagon receptor triple agonists

Semaglutide (Wegovy, Ozempic), liraglutide (Saxenda, Victoza), tirzepatide (Zepbound, Mounjaro)