glp-1 and depression Transformation 2.0: The RAs as Psychiatric Medications? Association between GLP-1 receptor agonist

Expert Opin Ther Pat (2020) 30:78194

Further, whilst some anecdotal and qualitative data suggests that GLP-1 RAs effectively reduced food-related thoughts (food noise) and support healthier eating behaviours, more objective data is needed

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As our findings are based on good-quality studies that were all multinational double-blind randomized placebo-control trials and our meta-analysis was based on a mean follow-up of 3.45 years (minimum 1.5 year maximum 5.4 years), the confounding and attrition bias are controlled, so the risk of unreliable results is diminished

Musculoskeletal & Anti-Inflammatory Effects GLP-1 receptors are present in: Chondrocytes Synovial tissues Macrophages Potential benefits include: Reduced inflammatory cytokines NF-B inhibition Reduced cartilage degradation Improvement in osteoarthritis inflammation The anti-inflammatory role of GLP-1 may become clinically important in rheumatologic and degenerative diseases

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