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Microdosing Split dosing protocols for improved tolerability

doi: 10.1056/NEJMOA1607141/SUPPL_FILE/NEJMOA1607141_DISCLOSURES.PDF 15 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

Br J Pharmacol (2015) 172(1):6479

The first person to be successfully treated was Leonard Thompson (figure 7)

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Click on the JSmol tab to take a closer look at how GLP-1 (PDB 6X18), semaglutide (PDB 7KI0), tirzepatide (PDB 7FIM), and orforglipron (PDB 6XOX) are able to stabilize the active form of the GLP-1 receptor, and compare these structures to that of the inactive GLP-1 receptor (PDB 6LN2)