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Archived from the original (PDF) on July 29, 2016

This metabolic route reduces the likelihood of drug-drug interactions and minimises the burden on liver enzyme systems, which is particularly relevant for patients taking multiple medications

There is no safety risk, but consistent early eating over time may meaningfully reduce treatment outcomes

First, the ability of semaglutide to improve glycemic control and reduce body weight contributes to a favorable metabolic environment that reduces inflammation, oxidative stress, and insulin resistancekey drivers of CV and arrhythmic outcomes (42)

Cox proportional hazards models were used to estimate hazard ratios (HRs)

In the base case analysis, the maximum treatment duration was assumed to be 2 years, and the efficacy data used were specific for the subgroup with BMI 30 kg/m 2 (treatment policy estimand)