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Doctors report that GLP-1 medications, originally approved for obesity and diabetes, are increasingly being used to help women with Polycystic Ovary Syndrome (PCOS) a hormonal disorder often tied to weight gain, insulin resistance, and fertility issues

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Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance

Combining bimagrumab with semaglutide led to 22% weight loss, with 93% of that loss coming from fat and minimal lean mass reduction