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Surgical revision (gastric pouch reduction or reversal of bypass) is considered only for severe, medically refractory cases after comprehensive evaluation by a specialist multidisciplinary team

doi: 10.1063/1.328693

While highly effective, it can cause common gastrointestinal side effects, including constipation

For instance, the STEP 1 extension study found that participants regained about two-thirds of their lost weight within a year of stopping semaglutide

Around 30 percent reported vomiting

It peaks in the first 24 to 48 hours after each injection and typically diminishes significantly after the first several weeks of treatment