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Dominant Route of Administration: Oral administration dominates with 75.6% share in 2025 , based on convenience, non-invasiveness, and patient compliance

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Other peptides, like GHRPs (Growth Hormone Releasing Peptides), may work through different mechanisms or receptors to achieve a similar outcome, but sermorelin's action is specifically focused on replicating the body's natural GHRH signal

Conversely, if you're achieving your metabolic goals with compounded semaglutide and managing costs effectively, switching introduces unnecessary medical and financial risk

Study quality was estimated by Newcastle-Ottawa Quality Assessment Scale (NOS) and Cochrane risk of bias (RoB) version 2 tool, and publication bias was estimated through forest plots and the Eggers test

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