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Treatment persistence data further underscores this concern

Discontinuation before conception, guided by each drugs pharmacokinetic profile, remains prudent to minimize potential fetal exposure: approximately 35 days for semaglutide (t 7 days), 2535 days for tirzepatide (t 5 days), and 3 days for liraglutide (t 13 h)

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Source: BioTrust

Muscle Mass Reduction Studies indicate that up to 40% of weight loss on some GLP-1 medications can actually be lean muscle rather than fat tissue
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