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Discontinuation due to adverse events was 11.3% at the highest dose versus 4.9% on placebo

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There was a reduced relative and absolute risk of MACE for semaglutide vs comparators across the entire continuum of CV risk

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This is particularly important if you are losing weight too quickly, feeling weak, or struggling to maintain a balanced diet.You should also seek advice if taste changes come with symptoms that could point to another medical issue
