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Regular follow-up appointments should include assessment of patient response, monitoring for adverse effects, and evaluation of the need for dose adjustments

Hydration is critical: aim for at least 810 glasses of water daily, as dehydration worsens nausea and can lead to constipation, a common semaglutide side effect

Dose titration strategies represent an important consideration

Individual response to NAD+ supplementation varies, and starting NAD+ levels, age, diet, and baseline metabolic health all affect outcomes

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Skipping meals or going long stretches without food can paradoxically increase hunger hormones once the medication's appetite-suppression window closes, leading to compensatory overeating