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Prespecified patient subgroups, endpoints and key study limitations of the included trials are summarised in Table 1

doi: 10.1007/s00198-017-4051-y 27 HouWHChangKCLiCYOuHT

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3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Du et al., 2022