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However, unlike the natural hormone, which breaks down in minutes, agonists are chemically modified to resist degradation, allowing them to remain active in the body for hours or days to provide continuous metabolic control

Various physiological functions can perform when activated by GLP-1 or synthetic agonists

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Patients taking insulin or sulfonylureas alongside GLP-1 therapy should monitor blood glucose carefully due to increased hypoglycaemia risk and may require dose adjustments

The duration of trials ranged from 6 to 26 weeks